What is the normal therapeutic range for Theophylline levels?

The normal therapeutic range for Theophylline levels is considered to be 10-20 mcg/mL. This range is established based on its effectiveness in treating conditions such as asthma and chronic obstructive pulmonary disease (COPD) while also minimizing the risk of toxicity. Maintaining levels within this range helps ensure that the medication effectively relaxes the muscles in the airways, promoting easier breathing, without causing adverse effects that can occur at higher concentrations.

Levels below 10 mcg/mL might be ineffective for symptom control, while levels above 20 mcg/mL increase the risk for side effects, such as nausea, vomiting, insomnia, and in severe cases, seizures or arrhythmias. Monitoring Theophylline levels is crucial for patients on this medication to achieve the desired therapeutic effect while avoiding toxicity.