Which of the following is a common side effect of calcium channel blockers?

Constipation is a well-documented side effect of calcium channel blockers. These medications work by inhibiting the influx of calcium ions into the vascular smooth muscle and cardiac muscle, leading to vasodilation and decreased heart rate. However, calcium also plays a significant role in the contractility of smooth muscles in the gastrointestinal tract. When calcium channel blockers are used, the decreased calcium availability can lead to decreased motility in the intestines, resulting in constipation for some patients.

It's important to note that while calcium channel blockers effectively manage conditions like hypertension and angina, they can cause gastrointestinal issues in some individuals. Recognizing this side effect is essential for healthcare providers to manage patient comfort and medication adherence properly.